Our Goal

Our goal is to identify and target key drivers of aberrant genome regulation in diseases such as Cancer. To achieve this, we combine functional genomic and epigenomic mapping tools (population and single-cell level gene expression and chromatin accessibility) with CRISPR-based genome manipulation (targeted gene editing, genome-level CRISPR screenings, and chromatin engineering) to identify and functionally characterize disease-associated aberrant genomic and epigenomic features.

We are also the Center for Genome Engineering as part of the Morphic consortium project, which aims to understand the function of every human gene. We are developing novel technologies and applying genome engineering and targeted protein depletion strategies to functionally characterize essential human genes in induced pluripotent stem cells (iPSC).    

Our lab is located in the Robert Lurie Comprehensive Cancer Center and is part of the Department of Obstetrics and Gynecology of Northwestern University, Feinberg School of Medicine.